1. Department of Physiology and Pharmacology; Federal University of Ceará; Fortaleza Ceará Brazil
2. Department of Clinical Medicine; Federal University of Ceará; Fortaleza Ceará Brazil
3. Department of Morphology; Federal University of Ceará; Fortaleza Ceará Brazil
4. Barts and the London School of Medicine and Dentistry; Queen Mary University of London; London UK