The impact of medetomidine on the protein-binding characteristics of MK-467 in canine plasma
Author:
Affiliation:
1. Department of Equine and Small Animal Medicine; Faculty of Veterinary Medicine; Helsinki Finland
2. University Veterinary Hospital, University College Dublin; Dublin Ireland
3. Admescope Ltd; Oulu Finland
Funder
Vetcare Ltd
ANIWEL graduate school, University of Helsinki, Finland
Publisher
Wiley
Subject
General Veterinary,Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jvp.12291/fullpdf
Reference14 articles.
1. Changes in plasma protein binding have little clinical relevance;Benet;Clinical Pharmacology Therapeutics,2002
2. A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066;Clineschmidt;Journal of Pharmacology and Experimental Therapeutics,1988
3. Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs;Enouri;American Journal of Veterinary Research,2008
4. The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs;Honkavaara;Veterinary Anaesthesia and Analgesia,2008
5. The effects of increasing doses of MK-467, a peripheral alpha (2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs;Honkavaara;Journal of Veterinary Pharmacology and Therapeutics,2011
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