Therapeutic index of inhaled corticosteroids in asthma: A dose–response comparison on airway hyperresponsiveness and adrenal axis suppression

Author:

Daley‐Yates Peter1ORCID,Brealey Noushin1,Thomas Sebin2,Austin Daren1,Shabbir Shaila3,Harrison Tim4,Singh Dave5ORCID,Barnes Neil67

Affiliation:

1. Clinical Pharmacology and Experimental Medicine GlaxoSmithKline plc Uxbridge UK

2. Biostatistics and Programming GlaxoSmithKline plc Bangalore India

3. Medicines Research Centre GlaxoSmithKline plc Stevenage UK

4. Respiratory Research Unit, Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK

5. Medicines Evaluation Unit, University of Manchester Manchester University NHS Foundation Trust Manchester UK

6. Global Medical Franchise GlaxoSmithKline plc Brentford UK

7. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

Funder

GlaxoSmithKline Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference35 articles.

1. Global Initiative for Asthma (GINA).Global Strategy for Asthma Management and Prevention 2019 update.https://ginasthma.org/wp-content/uploads/2019/06/GINA-2019-main-report-June-2019-wms.pdf. Accessed October 25 2019.

2. Inhaled corticosteroids: potency, dose equivalence and therapeutic index

3. ARNUITY ELLIPTA (fluticasone furoate inhalation powder) for oral inhalation use. Highlights of prescribing information. Updated June 2019.https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Arnuity_Ellipta/pdf/ARNUITY%2010ELLIPTA%2010PI%2010PIL%2010IFU.PDF. Accessed November 27 2019.

4. Flixotide 50 125 250 micrograms Evohaler.Fluticasone propionate. Summary of product characteristics. Updated 30 October 2019.https://www.medicines.org.uk/emc/product/3824/smpc. Accessed November 27 2019.

5. Pulmicort Turbohaler 200.Budesonide. Summary of product characteristics. Updated 15 June 2017.https://www.medicines.org.uk/emc/product/1385/smpc. Accessed November 27 2019.

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