Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4 + T cells-Reference-Cited by-同舟云学术

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Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4 + T cells

Published:2021-11-08 Issue: Volume: Page:
ISSN:1600-6135
Container-title:American Journal of Transplantation
language:en
Short-container-title:Am J Transplant

Author:

Agur Timna¹²^ORCID,Wedel Johannes¹²^ORCID,Bose Sayantan¹²^ORCID,Sahankumari A. G. Pramoda¹^ORCID,Goodman Daniel¹,Kong Sek Won³²^ORCID,Ghosh Chandra C.¹²,Briscoe David M.¹²^ORCID

Affiliation:

1. The Transplant Research Program and the Division of Nephrology Department of Pediatrics Boston Children’s Hospital Boston Massachusetts

2. Department of Pediatrics, Harvard Medical School Boston Massachusetts

3. Computational Health Informatics Program Boston Children's Hospital Boston Massachusetts

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.16872

Reference38 articles.

1. Regulation of the mevalonate pathway;Goldstein JL;Nature,1990

2. Mevalonate pathway: a review of clinical and therapeutical implications;Buhaescu I;Clin Biochem,2007

3. Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta‐analysis of randomised controlled trials;Gencer B;Lancet,2020

4. Immune modulatory effects of statins;Zeiser R;Immunol,2018

5. Statin therapy and autoimmune disease: from protein prenylation to immunomodulation;Greenwood J;Nat Rev Immunol,2006

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