Comparable kidney transplant outcomes in selected patients with a body mass index ≥ 40: A personalized medicine approach to recipient selection

Abstract

AbstractIntroductionMany kidney transplant (KT) centers decline patients with a body mass index (BMI) ≥40 kg/m2. This study's aim was to evaluate KT outcomes according to recipient BMI.MethodsWe performed a single‐center, retrospective review of adult KTs comparing BMI ≥40 patients (n = 84, BMI = 42 ± 2 kg/m2) to a matched BMI < 40 cohort (n = 84, BMI = 28 ± 5 kg/m2). Patients were matched for age, gender, race, diabetes, and donor type.ResultsBMI ≥40 patients were on dialysis longer (5.2 ± 3.2 years vs. 4.1 ± 3.5 years, p = .03) and received lower kidney donor profile index (KDPI) kidneys (40 ± 25% vs. 53 ± 26%, p = .003). There were no significant differences in prevalence of delayed graft function, reoperations, readmissions, wound complications, patient survival, or renal function at 1 year. Long‐term graft survival was higher for BMI ≥40 patients, including after adjusting for KDPI (BMI ≥40: aHR = 1.79, 95% CI = 1.09–2.9). BMI ≥40 patients had similar BMI change in the first year post‐transplant (delta BMI: BMI ≥ 40 +.9 ± 3.3 vs. BMI < 40 +1.1 ± 3.2, p = .59).ConclusionsOverall outcomes after KT were comparable in BMI ≥40 patients compared to a matched cohort with lower BMI with improved long‐term graft survival in obese patients. BMI‐based exclusion criteria for KT should be reexamined in favor of a more individualized approach.