Histoplasma antigen detection in unconfirmed pulmonary tuberculosis and cross‐reactivity with Aspergillus antigen in patients and in food in Jakarta, Indonesia

Author:

Wijaya Meiliyana12,Surja Sem Samuel2,Adawiyah Robiatul13456ORCID,Hariadi Ariananda3,Setianingrum Findra1345,Rozaliyani Anna1345,Burhan Erlina478,Tugiran Mulyati1345,Sjam Ridhawati1345,Denning David W.9,Wahyuningsih Retno310ORCID

Affiliation:

1. Study Program of Clinical Parasitology, Department of Parasitology, Faculty of Medicine Universitas Indonesia Jakarta Indonesia

2. Department of Parasitology, School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia Jakarta Indonesia

3. Department of Parasitology, Faculty of Medicine Universitas Indonesia Jakarta Indonesia

4. Indonesia Pulmonary Mycoses Centre (IPMC) Faculty of Medicine Universitas Indonesia and Persahabatan National Respiratory Referral Hospital Jakarta Indonesia

5. Master's Programme in Biomedical Sciences, Faculty of Medicine Universitas Indonesia Jakarta Indonesia

6. Infectious Diseases and Immunology Research Center (IDIRC), Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia Jakarta Indonesia

7. Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia Jakarta Indonesia

8. Persahabatan National Respiratory Referral Hospital Jakarta Indonesia

9. Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre Manchester United Kingdom

10. Department of Parasitology, Faculty of Medicine Universitas Kristen Indonesia Jakarta Indonesia

Abstract

AbstractPurposeH. capsulatum is endemic in Indonesia, but the value of Histoplasma antigen detection has not been studied.Patients and MethodsHistoplasma galactomannan (GM) ELISA was applied to sera of patients with unproven pulmonary tuberculosis (TB) and patients with a positive Aspergillus GM. Both Histoplasma and Aspergillus GM tests were performed to determine any possible cross‐reaction with certain foods.ResultsFourteen of 122 (11.5%) sera of patients with newly diagnosed clinical TB were positive for Histoplasma GM. The positivity rate in the serum of patients 5–6 and 12 months after TB diagnosis was 3.8% and 3.5%, respectively. Of 88 positive Aspergillus GM sera, 63 (71.6%) were also positive for Histoplasma GM. All tested foods were positive for Aspergillus GM, while 65% of foods were positive for Histoplasma GM.ConclusionGalactomannan is widespread in sera and food in Jakarta, possibly related to food consumption. Histoplasma and Aspergillus antigen detection for the diagnosis will require additional means of confirming the diagnosis; negative tests may be more helpful for ruling out invasive histoplasmosis and aspergillosis.

Funder

Medical Research Council

Publisher

Wiley

Subject

Infectious Diseases,Dermatology,General Medicine

Reference49 articles.

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