Affiliation:
1. Faculty of Medicine and Health School of Pharmacy The University of Sydney Sydney New South Wales Australia
2. Department of Infectious Diseases and Microbiology Royal Prince Alfred Hospital Camperdown New South Wales Australia
3. AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital Camperdown New South Wales Australia
4. Faculty of Medicine and Health Central Clinical School The University of Sydney Sydney New South Wales Australia
5. Department of Transplant Surgery Royal Prince Alfred Hospital Camperdown New South Wales Australia
6. Department of Pharmacy Royal Prince Alfred Hospital Camperdown New South Wales Australia
Abstract
AbstractBackgroundSurgical site infection (SSI) after liver transplant (LT) is common, but no studies have been conducted in Australia. The purpose of this study was to determine the proportion of patients who developed an SSI post‐LT in Australia's largest LT unit.MethodsThis was a single‐center retrospective cohort study. We included all LT recipients who were aged 18 years or more and received their transplant between March 1, 2018 and April 1, 2023. The primary outcome was to determine the proportion of LT recipients who developed an SSI within 30 days of transplantation.ResultsThere were 404 LTs performed during the study period, and 375 met inclusion criteria. Of these, 8% (n = 31/375) developed an SSI and were classified as superficial (3%, n = 12/375) or deep/organ space (5%, n = 19/375). The most common antibiotics used for prophylaxis were amoxicillin/clavulanate (75%, n = 281/375), followed by piperacillin/tazobactam (17%, n = 62/375). Independent risk factors associated with the development of SSI were Roux‐en‐Y hepaticojejunostomy (aOR 3.16, 95% CI 1.17–8.28, p = .02), operative time (per 60‐min increment) (aOR 1.23, 95% CI 1.02–1.48), and re‐operation (aOR 4.16, 95% CI 1.81–9.58, p < .01). Type of antibiotic received perioperatively was not significantly associated with SSI.ConclusionSSI occurred in 8% of LT recipients and was predominantly related to operation‐related factors rather than patient‐ or antibiotic‐related factors.
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