1. Department of Pharmacy, Radboud Institute of Health Sciences; Radboud University Medical Center; Nijmegen The Netherlands
2. Department of Pharmacology and Toxicology, Radboud Institute of Molecular Life Sciences; Radboud University Medical Center; Nijmegen The Netherlands
3. MRC Clinical Trials Unit at University College London; London UK
4. Department of Gastroenterology and Hepatology; Radboud University Medical Center; Nijmegen The Netherlands