Affiliation:
1. Department of Geriatrics, The First Affiliated Hospital, School of Medicine Zhejiang University Zhejiang China
2. Key Laboratory of Diagnosis and Treatment of Aging and Physic‐Chemical Injury Diseases of Zhejiang Province Zhejiang China
Abstract
AbstractBackground and AimNonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF) have been associated with sarcopenia. However, modifiers of this association have been less studied.MethodsThis study used data from the NHANES database 2011–2014 of the USA. Adults aged 18 years or older, had complete information of handgrip strength test and NAFLD and AHF status were eligible for inclusion. NAFLD was defined using the Fatty Liver Index (FLI). AHF was defined using the NAFLD fibrosis score (NFS). Univariate and multivariate logistic regression were performed to determine the associations between the study variables and prevalent NAFLD and AHF.ResultsA total of 19 931 participants were selected from the 2011–2014 NHANES database. The multivariate analysis showed that stronger grip strength was significantly and independently associated with decreased odds for NAFLD (tertile 2: adjusted odd ratio [aOR]: 0.41, 95% confidence interval [CI]: 0.29–0.59; tertile 3: aOR: 0.11, 95% CI: 0.05–0.24) and AHF (tertile 2: aOR: 0.66, 95% CI: 0.46–0.94; tertile 3: aOR: 0.28, 95% CI: 0.12–0.63). In stratified analyses, strongest grip strength was significantly associated with reduced odds for NAFLD regardless of age, body mass index, and having diabetes or not. Strongest grip strength was associated with reduced odds for NAFLD in individuals who had moderate to ideal physical activity (aOR: 0.31).ConclusionsGrip strength has an inverse association with prevalent NAFLD and AHF in the US population, which appears to be modified by physical activity level. Future prospective cohort studies are needed to clarify the role of physical activity in modifying the risks.
Funder
National Key Research and Development Program of China
Subject
Gastroenterology,Hepatology
Cited by
1 articles.
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