The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction

Author:

Gillespie Scarlett1,Holloway Paul M12,Becker Felix3,Rauzi Francesca4,Vital Shantel A2,Taylor Kirk A4,Stokes Karen Y2,Emerson Michael4ORCID,Gavins Felicity N E25ORCID

Affiliation:

1. Division of Brain Sciences; Imperial College London; London UK

2. Department of Molecular and Cellular Physiology; Louisiana State University Health Sciences Center - Shreveport; Shreveport LA USA

3. Department of General, Visceral and Transplant Surgery; University Hospital Muenster; Muenster Germany

4. Platelet Biology Group, National Heart and Lung Institute; Imperial College London; London UK

5. Department of Neurology; Louisiana State University Health Sciences Center - Shreveport; Shreveport LA USA

Funder

American Heart Association

National Centre for the Replacement, Refinement and Reduction of Animals in Research

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Pharmacology

Reference38 articles.

1. The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors;Alexander;Br J Pharmacol,2017a

2. The Concise Guide to PHARMACOLOGY 2017/18: Enzymes;Alexander;Br J Pharmacol,2017b

3. Activated platelets and atherosclerosis;Aukrust;Expert Rev Cardiovasc Ther,2010

4. Sulforaphane protects against cardiovascular disease via Nrf2 activation;Bai;Oxid Med Cell Longev,2015

5. Physical proximity and functional association of glycoprotein 1balpha and protein-disulfide isomerase on the platelet plasma membrane;Burgess;J Biol Chem,2000

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