The prevalence, complications, and risk factors for infantile hemangioma: a systematic review and meta‐analysis

Author:

Sun Yuming1,Zhao Jinhong2,Meng Yu34567,Luo Xiangyue1,Jiang Chufeng1,Deng Guangtong34567ORCID,Lei Shaorong1

Affiliation:

1. Department of Plastic and Cosmetic Surgery Xiangya Hospital, Central South University Changsha China

2. School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China

3. Department of Dermatology Xiangya Hospital, Central South University Changsha China

4. National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Xiangya Hospital, Central South University Changsha China

5. Furong Laboratory Xiangya Hospital, Central South University Changsha China

6. Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital, Central South University Changsha China

7. National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha China

Abstract

AbstractThe epidemiological landscape of infantile hemangioma (IH) has been extensively explored through diverse data sources; however, a scarcity of systematically pooled and quantified evidence from comprehensive global studies persists. In this meta‐analysis, we systematically review available literature to elucidate the prevalence, distribution of lesions, complications, and risk factors associated with IH. A meticulous search encompassing the Cochrane Library, PubMed, Embase, and Web of Science identified 3206 records, of which 55 studies met the inclusion criteria. We found that the overall prevalence of IH is 2.8% [95% confidence interval (CI): 1.5–4.4%] (31,274,396 infants), and IH was located more frequently in the head and neck with a prevalence of 47.4% (95% CI: 39.5–55.4%). The overall prevalence of complications of IH is 24.3% (95% CI: 18.6–30.5%), ulceration is 16.0% (95% CI: 10.4–21.2%), bleeding is 5.6% (95% CI: 3.3–8.5%), visual impairment is 5.6% (95% CI: 3.0–8.9%), infection is 2.8% (95% CI: 1.5–4.8%), subglottic obstruction is 1.5% (95% CI: 0.5–3.0%), respectively. Through 27 studies, we have evaluated 35 factors encompassing perinatal factors, socioeconomic factors, maternal complications, drug factors, and antepartum procedures, and identified 18 risk factors that increase the prevalence of IH. These findings can greatly assist clinicians and family members in effectively evaluating the risk of IH, and determining whether pregnant women should undergo intensified monitoring or preventive measures.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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