High expression of cereblon (CRBN) is associated with improved clinical response in patients with multiple myeloma treated with lenalidomide and dexamethasone

Author:

Heintel Daniel1,Rocci Alberto2,Ludwig Heinz1,Bolomsky Arnold1,Caltagirone Simona2,Schreder Martin1,Pfeifer Sabine1,Gisslinger Heinz3,Zojer Niklas1,Jäger Ulrich3,Palumbo Antonio2

Affiliation:

1. Department of Internal Medicine I; Center for Oncology and Haematology; Wilhelminenspital; Vienna; Austria

2. Divisione di Ematologia dell'Università di Torino; Azienda Ospedaliera S. Giovanni Battista; Ospedale Molinette; Torino; Italy

3. Division of Haematology and Haemostaseology; Department of Medicine I; Medical University of Vienna (MUW); Vienna; Austria

Publisher

Wiley

Subject

Hematology

Reference26 articles.

1. Lenalidomide and thalidomide: mechanisms of action-similarities and differences;Anderson;Seminars in Hematology,2005

2. Evidence of a role for activation of Wnt/ß-catenin signaling in the resistance of plasma cells to lenalidomide;Bjorklund;The Journal of Biological Chemistry,2011

3. High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance;Broyl;Blood,2012

4. What is the functional role of the thalidomide binding protein cereblon?;Chang;International Journal of Biochemistry and Molecular Biology,2011

5. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma;Dimopoulos;The New England Journal of Medicine,2007

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