Affiliation:
1. Department of Oral Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China
2. College of Stomatology, Shanghai Jiao Tong University Shanghai China
3. National Center for Stomatology Shanghai China
4. National Clinical Research Center for Oral Diseases Shanghai China
5. Shanghai Key Laboratory of Stomatology Shanghai China
Abstract
AbstractObjectiveWe aimed to investigate the value of individual laboratory tests and combinations of tests for predicting disease severity.MethodsWe retrospectively reviewed 62 patients with space infections in the oral and maxillofacial head and neck regions. Patients were divided into three groups according to severity. Laboratory tests associated with disease severity were identified.ResultsAs the severity of infection increased, leukocytes, neutrophils, C‐reactive protein (CRP), procalcitonin (PCT), soluble interleukin receptor (sILR) 2, IL6, and creatinine (CR) increased. In the ROC analysis of group 1 (moderate infection) versus group 2 (severe infection), the area under the curve (AUC) values for leukocytes (AUC = 0.724), neutrophils (AUC = 0.714), PCT (AUC = 0.762) and a combination of the 3 tests (AUC = 0.768) suggested a strong predictive value. Furthermore, in the ROC analysis of group 2 (severe infection) versus group 3 (extremely severe infection), the AUC values for CRP (AUC = 0.84), PCT (AUC = 0.799), sIL2R (AUC = 0.937), IL6 (AUC = 0.863) and a combination of the four tests (AUC = 0.943) suggested a strong predictive value.ConclusionsLeukocytes, neutrophils, and PCT were associated with multispace infection and high severity. CRP, PCT, sIL2R, and/or IL6 were associated with extremely severe infections occurring in the oral and maxillofacial head and neck regions.
Funder
National Natural Science Foundation of China
Subject
General Dentistry,Otorhinolaryngology