Affiliation:
1. Department of Neonatology, Affiliated Women's Hospital of Jiangnan University Wuxi Maternity and Child Health Care Hospital Wuxi China
2. Department of Physiopathology, Wuxi School of Medicine Jiangnan University Wuxi China
3. Research Institute for Reproductive Health and Genetic Diseases Affiliated Women's Hospital of Jiangnan University Wuxi China
4. Department of Pediatric Wuxi Yihe Gynaecology and Obstetrics Hospital Wuxi China
Abstract
AbstractQuercetin, a bioactive natural compound renowned for its potent anti‐inflammatory, antioxidant, and antiviral properties, has exhibited therapeutic potential in various diseases. Given that bronchopulmonary dysplasia (BPD) development is closely linked to inflammation and oxidative stress, and quercetin, a robust antioxidant known to activate NRF2 and influence the ferroptosis pathway, offers promise for a wide range of age groups. Nonetheless, the specific role of quercetin in BPD remains largely unexplored. This study aims to uncover the target role of quercetin in BPD through a combination of network pharmacology, molecular docking, computer analyses, and experimental evaluations.
Funder
National Natural Science Foundation of China