Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration

Author:

Traidl‐Hoffmann Claudia123ORCID,Afghani Jamie1,Akdis Cezmi34,Akdis Mübecel4ORCID,Aydin Handan5,Bärenfaller Katja4ORCID,Behrendt Heidrun6,Bieber Thomas37,Bigliardi Paul8,Bigliardi‐Qi Mei8,Bonefeld Charlotte Menné9ORCID,Bösch Stefanie1011,Brüggen Marie Charlotte31011ORCID,Diemert Sebastian12,Duchna Hans‐Werner313,Fähndrich Martina14,Fehr Danielle31011ORCID,Fellmann Marc15,Frei Remo31617,Garvey Lena H.1819ORCID,Gharbo Raschid20,Gökkaya Mehmet12,Grando Karin31011,Guillet Carole1011,Guler Erman21,Gutermuth Jan22,Herrmann Nadine23ORCID,Hijnen Dirk Jan24ORCID,Hülpüsch Claudia123,Irvine Alan D.25ORCID,Jensen‐Jarolim Erika2627ORCID,Kong Heidi H.28,Koren Hillel29,Lang Claudia C. V.3910,Lauener Roger30,Maintz Laura23ORCID,Mantel Pierre‐Yves3,Maverakis Emanuel31,Möhrenschlager Matthias13,Müller Svenja23ORCID,Nadeau Kari32ORCID,Neumann Avidan U.12,O'Mahony Liam3334ORCID,Rabenja Fahafahantsoa Rapelanoro35,Renz Harald36ORCID,Rhyner Claudio3,Rietschel Ernst3,Ring Johannes37,Roduit Caroline1630ORCID,Sasaki Mari16ORCID,Schenk Mirjam338,Schröder Jens39,Simon Dagmar40ORCID,Simon Hans‐Uwe4142,Sokolowska Milena34ORCID,Ständer Sonja43,Steinhoff Martin4445464748,Piccirillo Doris Straub3,Taïeb Alain49,Takaoka Roberto50,Tapparo Martin51,Teixeira Henrique22,Thyssen Jacob Pontoppidan52ORCID,Traidl Stephan5354ORCID,Uhlmann Miriam3,van de Veen Willem4,van Hage Marianne55ORCID,Virchow Christian56ORCID,Wollenberg Andreas575859,Yasutaka Mitamura4ORCID,Zink Alexander6061ORCID,Schmid‐Grendelmeier Peter3910ORCID

Affiliation:

1. Institute of Environmental Medicine and Integrative Health, Faculty of Medicine University of Augsburg Augsburg Germany

2. Institute of Environmental Medicine Helmholtz Zentrum München Augsburg Germany

3. Christine Kühne‐Center for Allergy Research and Education (CK‐CARE) Medicine Campus Davos Switzerland

4. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich Zurich Switzerland

5. AbbVie Inc. North Chicago Illinois USA

6. Center for Allergy and Environment (ZAUM) Technische Universität München Germany

7. Davos Biosciences Davos Switzerland

8. University of Minnesota Minneapolis Minnesota USA

9. Department of Immunology and Microbiology, The LEO Foundation Skin Immunology Research Center University of Copenhagen Copenhagen Denmark

10. Department of Dermatology, Allergy Unit University Hospital of Zürich Zürich Switzerland

11. Faculty of Medicine University of Zürich Zürich Switzerland

12. Almirall Hermal GmbH Reinbek Germany

13. Hochgebirgsklinik Davos Davos Switzerland

14. LEO Pharmaceutical Products Sarath Ltd Zürich Switzerland

15. Pfizer Switzerland AG Zürich Switzerland

16. Department of Pediatrics, Division of Respiratory Medicine and Allergology Bern University Hospital Bern Switzerland

17. Department of BioMedical Research (DBMR) University of Bern Bern Switzerland

18. Department of Dermatology and Allergy, Allergy Clinic Copenhagen University Hospital–Herlev and Gentofte Copenhagen Denmark

19. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

20. Psychosomatic Department Hochgebirgsklinik Davos Switzerland

21. Pfizer Istanbul Turkey

22. Universitair Ziekenhuis Brussel Belgium

23. Department of Dermatology and Allergy University Hospital Bonn Bonn Germany

24. Diakonessenhuis Utrecht Zeist Doorn Locatie Utrecht Erasmus MC, University Medical Center Utrecht Utrecht Netherlands

25. Department of Clinical Medicine Trinity College Dublin Dublin Ireland

26. Center of Pathophysiology, Infectiology and Immunology Institute of Pathophysiology and Allergy Research, Medical University of Vienna Vienna Austria

27. The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna Vienna Austria

28. Dermatology Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda Maryland USA

29. Environmental Health LLC Durham North Carolina USA

30. Ostschweizer Kinderspital St. Gallen St.Gallen Switzerland

31. Department of Dermatology University of California Davis Sacramento California USA

32. Stanford University School of Medicine Stanford California USA

33. APC Microbiome Ireland University College Cork Cork Ireland

34. Department of Medicine and School of Microbiology University College Cork Cork Ireland

35. Faculty of Médicine Antananarivo Madagascar

36. Institute of Laboratory Medicine, Philipps University Marburg Germany

37. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein Technische Universität München Munich Germany

38. Institute of Tissue Medicine and Pathology University of Bern Bern Switzerland

39. Klinik für Dermatologie, Venerologie und Allergologie Universitätsklinikum Schleswig‐Holstein (UK‐SH) Kiel Germany

40. Department of Dermatology Inselspital, Bern University Hospital, University of Bern Bern Switzerland

41. Institute of Pharmacology, University of Bern Bern Switzerland

42. Institute of Biochemistry, Brandenburg Medical School Neuruppin Germany

43. Center for Chronic Pruritus and Department of Dermatology University Hospital Münster Münster Germany

44. Department of Dermatology and Venereology Hamad Medical Corporation Doha Qatar

45. Translational Research Institute, Academic Health System, Hamad Medical Corporation Doha Qatar

46. Dermatology Institute, Academic Health System, Hamad Medical Corporation Doha Qatar

47. School of Medicine Weill Cornell Medicine‐Qatar Ar‐Rayyan Qatar

48. College of Medicine Qatar University Doha Qatar

49. INSERM 1312 University of Bordeaux Bordeaux France

50. Department of Dermatology, Faculdade de Medicina Hospital das Clínicas, Universidade de São Paulo São Paulo São Paulo Brazil

51. Bencard Allergie GmbH München Munich Germany

52. Department of Dermatology and Venerology Bispebjerg Hospital, University of Copenhagen Copenhagen Denmark

53. Department of Dermatology and Allergy Hannover Medical School Hannover Germany

54. Cluster of Excellence RESIST (EXC 2155) Hannover Medical School Hannover Germany

55. Department of Medicine Solna, Division of Immunology and Allergy Karolinska Institute and Karolinska University Hospital Stockholm Solna Sweden

56. Department of Pneumology, Intensive Care Medicine, Center for Internal Medicine Universitätsmedizin Rostock Rostock Germany

57. Department of Dermatology and Allergy Ludwig‐Maximilian‐University Munich Germany

58. Department of Dermatology and Allergy University Hospital Augsburg Augsburg Germany

59. Comprehensive Center of Inflammation Medicine University Hospital Schleswig Holstein Campus Luebeck Lubeck Germany

60. Department of Dermatology and Allergy School of Medicine, Technical University of Munich Munich Germany

61. Department of Medicine Solna, Division of Dermatology and Venereology Karolinska Institutet Stockholm Sweden

Abstract

AbstractThe 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient‐centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world.

Publisher

Wiley

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