An S-warfarin and AZD1981 interaction:in vitroand clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator-Reference-Cited by-同舟云学术

An S-warfarin and AZD1981 interaction:in vitroand clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator

Author:

Grime Ken¹,Pehrson Rikard¹,Nordell Pär²,Gillen Michael³,Kühn Wolfgang⁴,Mant Timothy⁵,Brännström Marie¹,Svanberg Petter¹,Jones Barry²,Brealey Clive⁶

Affiliation:

1. Respiratory, Inflammation & Autoimmune Disease Department of DMPK; AstraZeneca R&D; Gothenburg Sweden

2. Drug Safety and Metabolism; AstraZeneca R&D; Gothenburg Sweden

3. AstraZeneca Early Clinical Development; Gaithersburg MD USA

4. Quintiles Allergy, Respiratory, Infectious Diseases & Vaccines Therapeutic Science & Strategy Unit; Uppsala Sweden

5. Quintiles Drug Research Unit at Guy's Hospital; London UK

6. Roche DMPK; Basel Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

Reference43 articles.

4. AstraZeneca Development Drug Metabolism and Bioanalysis Report, Document Number 122-368 (Study Number WN-200439) in vitro 14

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