Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer

Author:

Brown Kathryn1,Comisar Craig2,Witjes Han2,Maringwa John2,de Greef Rik2,Vishwanathan Karthick3,Cantarini Mireille4,Cox Eugène2

Affiliation:

1. UCB; Slough UK

2. Quantitative Solutions, a Certara company; Breda The Netherlands

3. AstraZeneca; Waltham USA

4. AstraZeneca, Alderley Park; UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference11 articles.

1. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands;Southan;Nucl Acids Res,2016

2. The Concise Guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015

3. AZD9291, an irreversible EGFR TKI, overcomes T790 M-mediated resistance to EGFR inhibitors in lung cancer;Cross;Cancer Discov,2014

4. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer;Jänne;N Engl J Med,2015

5. AZD9291 in treatment-naive EGFRm advanced NSCLC: AURA first-line cohort. Presented in mini oral session, WCLC Denver 6-9 September 2015;Ramalingam;J Thorac Oncol,2015

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