Point‐of‐care platelet function testing results in a dog with Bernard–Soulier syndrome

Abstract

AbstractBernard–Soulier syndrome (BSS), also known as hemorrhagiparous thrombocytic dystrophy (OMIA 002207–9615), is a rare defect in platelet function recognized in both dogs and humans. It is caused by a deficiency in glycoprotein 1b‐IX‐V, the platelet surface protein which acts as a receptor for the von Willebrand factor. The characteristic features of BSS in humans and dogs include macrothrombocytes and mild‐to‐moderate thrombocytopenia with a bleeding tendency. This condition has previously been reported in European Cocker Spaniel dogs; however, the results of platelet function tests in these animals have not been reported. This case report describes a European Cocker Spaniel dog with spontaneously occurring Bernard–Soulier syndrome and the results of point‐of‐care platelet function tests, including a prolonged buccal mucosal bleeding time (>8 min), prolongation (>300 s) of PFA‐200 COL/ADP, COL/EPI, and P2Y closure times, and reduced aggregation (15%–48%) with Plateletworks ADP, but with normal aggregation (92%) with Plateletworks AA. This is the first description of the results of platelet function tests in canine Bernard–Soulier syndrome.