Immune‐mediated necrotizing myopathy with concomitant development of Kikuchi–Fujimoto disease

Author:

Ichikawa Takanori1,Furukawa Ryo1,Shimojima Yasuhiro1ORCID,Hoshino Yumi1,Kishida Dai1,Sekijima Yoshiki1

Affiliation:

1. Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine Matsumoto Japan

Abstract

AbstractImmune‐mediated necrotizing myopathy (IMNM) is a distinct type of idiopathic inflammatory myositis, pathologically characterized by myofiber necrosis and degeneration in the absence of lymphocyte infiltration. Herein, we present a case of IMNM with concomitant development of Kikuchi–Fujimoto disease (KFD), characterized by histiocytic necrotizing lymphadenitis, in a 36‐year‐old woman who had a treatment history for rheumatoid arthritis (RA). Treatment with oral prednisolone and tacrolimus as immunosuppressants resulted in the remission of the skeletomuscular involvement and lymphadenopathy. To the best of our knowledge, this is the first report of IMNM and KFD developing concomitantly during the clinical course of RA.

Publisher

Wiley

Subject

Rheumatology

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1. Methotrexate;Reactions Weekly;2023-09-30

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