Association between glucocorticoid discontinuation and incidence of infection in older adults with rheumatoid arthritis: A retrospective cohort study

Author:

Goto Yutaka1ORCID,Nagafuchi Hiroko1ORCID,Kaga Yasuyuki23ORCID,Kawahata Kimito1ORCID

Affiliation:

1. Division of Rheumatology, Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Japan

2. Department of Practical Management of Medical Information St. Marianna University School of Medicine Kawasaki Japan

3. EPS Corporation Tokyo Japan

Abstract

AbstractAimOld age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation.MethodsMedical records of patients with RA aged ≥60 years were retrieved, and the association between GC use and the incidence of infection was investigated. The participants were divided into three groups: GC‐continued, GC‐discontinued, and non‐GC; the incidence of infection was statistically analyzed. Furthermore, patient treatments and comorbidities were examined.ResultsAmong 389 patients with RA included in the study (n = 122, n = 126, and n = 141 in the GC‐discontinued, GC‐continued, and non‐GC groups, respectively), 65 (16.7%) patients developed infection, and the incidence of infection was significantly higher in the GC‐continued group than in the GC‐discontinued (p = .021) and non‐GC (p = .0003) groups; there was no significant difference between the non‐GC and GC‐discontinued groups (p = .659). The GC‐discontinued group was more likely to require biologic use throughout the disease course than the other two groups. Comorbidities, especially malignancies (p = .004), were more common in the GC‐continued group than in the GC‐discontinued group (p = .007).ConclusionIn patients with RA aged ≥60 years receiving GCs, GC discontinuation reduced the incidence of infection. Therefore, a further analysis of factors that help reduce GC use is necessary.

Publisher

Wiley

Subject

Rheumatology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3