Affiliation:
1. Department of Orthopedics Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China
2. Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine Wuxi China
3. Department of Orthopedic Surgery Wuxi Huishan District People's Hospital Wuxi China
4. School of Chinese Medicine, School of Integrated Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing China
5. Chinese Medicine Centre (International Collaboration between Western Sydney University and Beijing University of Chinese Medicine), Western Sydney University Sydney New South Wales Australia
Abstract
AbstractBackgroundMicroRNAs (miRNAs) are widely recognized in the pathogenesis of autoimmune disease. As a key regulatory factor, miRNAs have introduced new biomarkers for the early diagnosis of rheumatoid arthritis (RA) and provided a favorable research direction for the development of novel therapeutic targets. This study aimed to explore the hotspots of miRNA research related to RA published from different countries, organizations, and authors.MethodsFrom 2001 to 2022, publications on miRNA related to RA were identified in the Web of Science database. The total and annual number of publishments, citations, impact factor, H‐index, productive authors, and involved journals were collected for quantitative and qualitative comparisons.ResultsA total of 29 countries/regions in the world have participated in the research of miRNAs and RA over the past two decades, and China (760, 53.18%) and the United States (233, 16.31%) account for the majority of the total publications. China dominated in total citation (17881) and H‐index (62). A total of 507 academic journals have published articles in related fields, and Frontiers in Immunology published the most (53, 3.71%). Chih‐hsin Tang of the China Medical University has published the most papers (16, 1.2%). Stanczyk (2008) published the most cited article Altered expression of miRNAs in synovial fibroblasts and synovial tissue in rheumatoid arthritis in Arthritis and Rheumatism, with 660 citations. Inflammation is the high‐frequency keyword outside of RA and miRNAs, and related researches have mainly focused on miR‐146a and miR‐155.ConclusionsIn the past two decades, extensive and continuous research has been conducted to investigate the role of miRNAs in RA, and miRNAs are widely recognized in the pathogenesis of RA. Related research has mainly focused on miR‐146a and miR‐155 that have shown promising results as key factors in RA experimental models. Focusing on clinical applications and translational research may be the future research direction and hotspot based on molecular biology basic research and mechanism exploration.
Funder
Natural Science Foundation of Jiangsu Province