The association between genetic polymorphisms of matrix metalloproteinases and knee osteoarthritis: A systematic review and meta‐analysis

Abstract

AbstractAimTo investigate the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA).MethodsThis meta‐analysis study systematically retrieved relevant studies from PubMed, Embase, the Cochrane Central, Wanfang Data, CNKI, and SinoMed up to November 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP gene polymorphisms and OA.ResultsA total of nine case–control studies comprising 1719 knee OA patients and 1904 controls were included in this meta‐analysis. The results revealed that MMP‐1‐1607 (rs1799750) 1G/2G polymorphism was not significantly associated with knee OA risk in four genetic models (OR (95% CI): allele model: 0.89 (0.57, 1.40), p = .615); dominant mode: 0.82 (0.47, 1.44), p = .486; recessive model: 0.88 (0.49, 1.57), p = .659; homozygote model: 0.79 (0.34, 1.82), p = .576. The association was significant for dominant model of MMP‐3 C/T: 1.54 (1.10–2.15), p = .013, especially in Asian ethnicity (1.63 (1.11, 2.39), p = .013). Variants of MMP‐13 C/T polymorphism were associated with increased risk of knee OA development based on dominant model: 1.56 (1.19, 2.06), p = .001 and homozygote model: 2.12 (1.44, 3.13), p < .001, and there were significant associations between MMP‐13 C/T polymorphism and knee OA risk in Asian ethnicity under different genetic models (all p > .05).ConclusionsPresent evidence suggested that the gene polymorphisms of MMP‐1‐1607 1G/2G may not be associated with the risk of OA. But, the dominant model of MMP‐3 and MMP‐13 polymorphisms in Asian ethnicity was significantly correlated with knee OA.