Association between glucocorticoid discontinuation and incidence of infection in older adults with rheumatoid arthritis: A retrospective cohort study

Abstract

AbstractAimOld age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation.MethodsMedical records of patients with RA aged ≥60 years were retrieved, and the association between GC use and the incidence of infection was investigated. The participants were divided into three groups: GC‐continued, GC‐discontinued, and non‐GC; the incidence of infection was statistically analyzed. Furthermore, patient treatments and comorbidities were examined.ResultsAmong 389 patients with RA included in the study (n = 122, n = 126, and n = 141 in the GC‐discontinued, GC‐continued, and non‐GC groups, respectively), 65 (16.7%) patients developed infection, and the incidence of infection was significantly higher in the GC‐continued group than in the GC‐discontinued (p = .021) and non‐GC (p = .0003) groups; there was no significant difference between the non‐GC and GC‐discontinued groups (p = .659). The GC‐discontinued group was more likely to require biologic use throughout the disease course than the other two groups. Comorbidities, especially malignancies (p = .004), were more common in the GC‐continued group than in the GC‐discontinued group (p = .007).ConclusionIn patients with RA aged ≥60 years receiving GCs, GC discontinuation reduced the incidence of infection. Therefore, a further analysis of factors that help reduce GC use is necessary.