Role of the α1blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial

Author:

Kenna George A.1,Haass-Koffler Carolina L.23,Zywiak William H.14,Edwards Steven M.5,Brickley Michael B.2,Swift Robert M.16,Leggio Lorenzo23

Affiliation:

1. Department of Psychiatry and Human Behavior; Center for Alcohol and Addiction Studies; Brown University; Providence RI USA

2. Department of Behavioral and Social Sciences; Center for Alcohol and Addiction Studies; Brown University; Providence RI USA

3. Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; National Institutes of Health; Bethesda MD USA

4. Decision Sciences Institute; PIRE; Pawtucket RI USA

5. Department of Psychology; University of Nebraska-Lincoln; Lincoln NE USA

6. Veterans Affairs Medical Center; Providence RI USA

Funder

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIAAA Division of Intramural Clinical and Biological Research

National Institute on Drug Abuse (NIDA) Intramural Research Program

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Reference43 articles.

1. Terazosin, doxazosin, and prazosin: current clinical experience;Akduman;Urology,2001

2. Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition;Amit;Arch Int Pharmacodyn Ther,1977

3. The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior;Anton;Alcohol Clin Exp Res,1995

4. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial;Anton;JAMA,2006

5. Does family history of alcoholism moderate naltrexone's effects on alcohol use?;Capone;J Stud Alcohol Drugs,2011

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