Clinical epidemiology of COVID‐19 in people of black ethnicity living with HIV in the UK

Author:

Ottaway Zoe12ORCID,Campbell Lucy12,Cechin Laura R.1,Patel Nisha1,Fox Julie23,Burns Fiona45,Hamzah Lisa6,Kegg Stephen7,Rosenvinge Melanie7,Schoeman Sarah8,Price David9,Jones Rachael10,Clarke Amanda11,Maan Irfaan512ORCID,Ustianowski Andrew13,Onyango Denis14,Tariq Shema512ORCID,Miller Robert F.512,Post Frank A.12ORCID,

Affiliation:

1. King's College Hospital NHS Foundation Trust London UK

2. King's College London London UK

3. Guys and St Thomas's NHS Foundation Trust London UK

4. Royal Free London NHS Foundation Trust London UK

5. Institute for Global Health University College London London UK

6. St George's University Hospital NHS Foundation Trust London UK

7. Lewisham and Greenwich NHS Trust London UK

8. Leeds Teaching Hospitals NHS Trust Leeds UK

9. Newcastle Hospitals NHS Foundation Trust Newcastle UK

10. Chelsea and Westminster NHS Foundation Trust London UK

11. University Hospitals Sussex NHS Foundation Trust Brighton UK

12. Central and North West London NHS Foundation Trust London UK

13. North Manchester General Hospital Manchester UK

14. Africa Advocacy Foundation London UK

Abstract

AbstractObjectivesTo describe the clinical epidemiology of COVID‐19 in people of black ethnicity living with HIV in the UK.MethodsWe investigated the incidence and factors associated with COVID‐19 in a previously established and well‐characterized cohort of black people with HIV. Primary outcomes were COVID‐19 acquisition and severe COVID‐19 disease (requiring hospitalization and/or resulting in death). Cumulative incidence was analysed using Nelson–Aalen methods, and associations between demographic, pre‐pandemic immune‐virological parameters, comorbidity status and (severe) COVID‐19 were identified using Cox regression analysis.ResultsCOVID‐19 status was available for 1847 (74%) of 2495 COVID‐AFRICA participants (median age 49.6 years; 56% female; median CD4 cell count = 555 cells/μL; 93% HIV RNA <200 copies/mL), 573 (31%) of whom reported at least one episode of COVID‐19. The cumulative incidence rates of COVID‐19 and severe COVID‐19 were 31.0% and 3.4%, respectively. Region of ancestry (East/Southern/Central vs. West Africa), nadir CD4 count and kidney disease were associated with COVID‐19 acquisition. Diabetes mellitus [adjusted hazard ratio (aHR) = 2.39, 95% confidence interval (CI): 1.26–4.53] and kidney disease (aHR = 2.53, 95% CI: 1.26–4.53) were associated with an increased risk, and recent CD4 count >500 cells/μL (aHR = 0.49, 95% CI: 0.25–0.93) with a lower risk of severe COVID‐19.ConclusionsRegion of ancestry was associated with COVID‐19 acquisition, and immune and comorbidity statuses were associated with COVID‐19 disease severity in people of black ethnicity living with HIV in the UK.

Funder

Gilead Sciences

Publisher

Wiley

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