Metabolic‐associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults

Abstract

AbstractBackground and AimsGiven that the majority of colorectal cancers (CRCs) develop from high‐risk adenomas, identifying risk factors for high‐risk adenomas is important. The relationship between metabolic dysfunction‐associated fatty liver disease (MAFLD) and the risk of colorectal adenoma in young adults remains unclear. We aimed to evaluate this relationship in adults <50 (younger) and ≥50 (older) years of age.MethodsThis cross‐sectional study included 184 792 Korean adults (80% <50 years of age) who all underwent liver ultrasound and colonoscopy. Participants were grouped into those with and without MAFLD and classified by adenoma presence into no adenoma, low‐risk adenoma, or high‐risk adenoma (defined as ≥3 adenomas, any ≥10 mm, or adenoma with high‐grade dysplasia/villous features).ResultsThe prevalence of low‐ and high‐risk adenomas among young and older adults was 9.6% and 0.8% and 22.3% and 4.8%, respectively. MAFLD was associated with an increased prevalence of low‐ and high‐risk adenomas in young and older adults. Young adults with MAFLD had a 1.30 (95% CIs 1.26–1.35) and 1.40 (1.23–1.59) times higher prevalence of low‐ and high‐risk adenomas, respectively, compared to those without MAFLD. These associations were consistent even in lean adults (BMI < 23 kg/m2) and those without a family history of CRC.ConclusionsMAFLD is associated with an increased prevalence of low‐ and high‐risk adenomas in Korean adults, regardless of age or obesity status. Whether reducing metabolic risk factors, such as MAFLD, reduces the risk of precancerous lesions and ultimately reduces the risk of early‐onset CRC requires further investigation.