Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non‐target sites, for DAA‐based treatment and retreatment outcome

Author:

Fahnøe Ulrik12,Pedersen Martin S.1234,Sølund Christina15,Ernst Anja6,Krarup Henrik B.67ORCID,Røge Birgit T.8,Christensen Peer B.910,Laursen Alex L.11,Gerstoft Jan1213,Thielsen Peter14,Madsen Lone G.1315,Pedersen Anders G.16,Schønning Kristian31317,Weis Nina513,Bukh Jens125ORCID

Affiliation:

1. Copenhagen Hepatitis C Program (CO‐HEP), Department of Infectious Diseases Copenhagen University Hospital Hvidovre Denmark

2. Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

3. Department of Clinical Microbiology Copenhagen University Hospital Hvidovre Denmark

4. Department of Science and Environment Roskilde University Roskilde Denmark

5. Department of Infectious Diseases Copenhagen University Hospital Hvidovre Denmark

6. Department of Molecular Diagnostics Aalborg University Hospital Aalborg Denmark

7. Department of Medical Gastroenterology Aalborg University Hospital Aalborg Denmark

8. Department of Medicine Lillebaelt Hospital Kolding Denmark

9. Department of Infectious Diseases Odense University Hospital Odense Denmark

10. Department of Clinical Research, Faculty of Health Sciences University of Southern Denmark Odense Denmark

11. Department of Infectious Diseases Aarhus University Hospital Skejby Denmark

12. Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark

13. Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

14. Department of Gastroenterology Copenhagen University Hospital Herlev Denmark

15. Department of Medical Gastroenterology Zealand University Hospital Køge Denmark

16. Department of Health Technology, Section for Bioinformatics Technical University of Denmark Lyngby Denmark

17. Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet Denmark

Funder

Novo Nordisk Fonden

Innovationsfonden

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

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