The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

Author:

Tonello Raquel12,Fusi Camilla3,Materazzi Serena3,Marone Ilaria M3,De Logu Francesco3,Benemei Silvia3,Gonçalves Muryel C3,Coppi Elisabetta3,Castro-Junior Celio J4,Gomez Marcus Vinicius4,Geppetti Pierangelo3,Ferreira Juliano2,Nassini Romina3

Affiliation:

1. Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica; Universidade Federal de Santa Maria; Santa Maria Brazil

2. Departmento de Farmacologia; Universidade Federal de Santa Catarina; Florianópolis Brazil

3. Department of Health Sciences, Section of Clinical Pharmacology and Oncology; University of Florence; Florence Italy

4. Núcleo de Pós-graduação; Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte; Belo Horizonte Brazil

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

Subject

Pharmacology

Reference47 articles.

1. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors;Alexander;Br J Pharmacol,2015a

2. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels;Alexander;Br J Pharmacol,2015b

3. TRPA1 antagonists as potential analgesic drugs;Andrade;Pharmacol Ther,2012

4. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents;Andre;J Clin Invest,2008

5. Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1);Andreev;J Biol Chem,2008

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