Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment

Author:

Derissen Ellen J. B.1,Jacobs Bart A. W.1,Huitema Alwin D. R.1,Rosing Hilde1,Schellens Jan H. M.23,Beijnen Jos H.13

Affiliation:

1. Department of Pharmacy & Pharmacology; Antoni van Leeuwenhoek Hospital - The Netherlands Cancer Institute and MC Slotervaart; Louwesweg 6 1066 EC Amsterdam The Netherlands

2. Department of Clinical Pharmacology; The Netherlands Cancer Institute; Plesmanlaan 121 1066 CX Amsterdam The Netherlands

3. Science Faculty, Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmaco-Epidemiology & Clinical Pharmacology; Utrecht University; P.O. Box 80082 3508 TB Utrecht The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference25 articles.

1. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue;Miwa;Eur J Cancer,1998

2. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients;Schüller;Cancer Chemother Pharmacol,2000

3. Mechanisms of action and modulation of fluorouracil;Grem;Semin Radiat Oncol,1997

4. 5-Fluorouracil derivatives: a patent review;Álvarez;Expert Opin Ther Pat,2012

5. Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5′-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes;Peters;Cancer Res,1986

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