Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism - a preliminary study

Author:

Keszthelyi D.12,Troost F. J.12,Jonkers D. M.12,van Eijk H. M.3,Dekker J.1,Buurman W. A.4,Masclee A. A. M.12

Affiliation:

1. Top Institute Food and Nutrition; Wageningen The Netherlands

2. Division of Gastroenterology-Hepatology; Department of Internal Medicine; Maastricht University Medical Center+; Maastricht The Netherlands

3. Department of Surgery; Maastricht University Medical Center+; Maastricht The Netherlands

4. School for Mental Health and Neuroscience; Division Neuroscience; Maastricht University Medical Centre+; Maastricht The Netherlands

Funder

Top Institute Food and Nutrition

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

Reference49 articles.

1. The serotonin precursor 5-hydroxytryptophan induces rectal hyperalgesia in patients with Irritable Bowel Syndrome (IBS);Keszthelyi;Neurogastroent Motil,2012

2. The serotonin signaling system: from basic understanding to drug development for functional GI disorders;Gershon;Gastroenterology,2007

3. Serotonin in the gastrointestinal tract;Camilleri;Curr Opin Endocrinol Diabetes Obes,2009

4. Serotonin and GI clinical disorders;Spiller;Neuropharmacology,2008

5. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome;Coates;Gastroenterology,2004

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