P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

Author:

Laird Christopher T.1ORCID,Hassanein Wessam1,O'Neill Natalie A.1ORCID,French Beth M.1ORCID,Cheng Xiangfei1,Fogler William E.2,Magnani John L.2,Parsell Dawn1,Cimeno Arielle1ORCID,Phelps Carol J.3,Ayares David3,Burdorf Lars1,Azimzadeh Agnes M.1,Pierson Richard N.12

Affiliation:

1. University of Maryland SOM; Baltimore MD USA

2. GlycoMimetics, Inc; Rockville MD USA

3. Revivicor, Inc; Blacksburg VA USA

Funder

United Therapeutics Corporation

University of Maryland

Publisher

Wiley

Subject

Transplantation,Immunology

Reference38 articles.

1. Higginbotham L Kim S Mathews D Late renal xenograft failure is antibody-mediated: description of the longest-reported survival in pig-to-primate renal xenotransplantation 2016

2. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nature;Mohiuddin;Communications,2016

3. A bridge to somewhere: 25-day survival after pig-to-baboon liver xenotransplantation;Shah;Ann Surg,2016

4. Neutrophil adhesion and activation under flow;Zarbock;Microcirculation,2009

5. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow;Zarbock;Blood,2011

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