Association between area under the C‐peptide curve during an oral glucose tolerance test and diabetic retinopathy in type 2 diabetes patients

Author:

Zhang Cong1,Ma Xuefei1,Lin Wenjian1,Xu Qian1,Li Hongxue1,Xu Chengye1,Hao Ming1,Kuang Hongyu1ORCID

Affiliation:

1. Department of Endocrinology The First Affiliated Hospital of Harbin Medical University Harbin China

Abstract

AbstractAims/IntroductionTo evaluate the relative contributions of the area under the C‐peptide curve (AUCC) in diabetic retinopathy (DR) during an oral glucose tolerance test and C‐peptide release test in patients with type 2 diabetes.Materials and MethodsWe retrospectively analyzed the data of 969 patients. Their general characteristics were retrieved. A series of parameters for assessing pancreatic β‐cells function, such as the AUCC for six time periods: 0–60 min (AUCC0–60), 0–120 min (AUCC0–120), 0–180 min (AUCC0–180), 60–120 min (AUCC60–120), 60–180 min (AUCC60–180) and 120–180 min (AUCC120–180); the area under the glucose‐time curve for six time periods: 0–60 min (AUCG0–60), 0–120 min (AUCG0–120), 0–180 min (AUCG0–180), 60–120 min (AUCG60–120), 60–180 min (AUCG60–180) and 120–180 min (AUCG120–180) and their related indexes, were calculated through 0–180 min oral glucose tolerance test and C‐peptide release test. We used univariate analysis to examine the potential factors affecting DR. Spearman's correlation was used to analyze the correlation between AUCC‐related indexes and DR. The logistic regression model was used to investigate AUCC and its related indexes’ contribution to incidence DR. A smooth curve fitting model was used to determine the correlation, non‐linear relationship, and threshold effect between AUCC and DR.ResultsOf the 969 patients with type 2 diabetes, 469 (48.40%) and 500 (51.60%) were classified as the DR group and non‐DR group. Compared with the non‐DR group, the DR patients had lower AUCC and AUCC/AUCG. Spearman's correlation analysis showed that AUCC‐related indexes were all negatively correlated with DR. The logistic regression analysis determined that there were associations between AUCC and DR in the adjusted models. The odds ratio values of AUCC0–60, AUCC0–120, AUCC0–180, AUCC0–60/AUCG0–60, AUCC0–120/AUCG0–120, AUCC0–180/AUCG0–180, AUCC60–120, AUCC60–180, AUCC120–180, AUCC60–120/AUCG60–120, AUCC60–180/AUCG60–180 and AUCC120–180/AUCG120–180 were 0.817 (0.750, 0.890), 0.925 (0.895, 0.955), 0.951 (0.932, 0.970), 0.143 (0.060, 0.340), 0.194 (0.093, 0.406), 0.223 (0.116, 0.427), 0.886 (0.842, 0.933), 0.939 (0.915, 0.963), 0.887 (0.846, 0.930), 0.253 (0.133, 0.479), 0.282 (0.160, 0.497) and 0.355 (0.220, 0.573), respectively. AUCC showed a non‐linear relationship with DR, with an inflection point. The inflection points of AUCC180/AUCG180, AUCC60–120, AUCC60–180, AUCC120–180, AUCC60–120/AUCG60–120, AUCC60–180/AUCG60–180, AUCC120–180/AUCG120–180 and DR were 17.51, 0.542, 6.6, 15.7, 8.23, 0.534, 0.593 and 0.808 (P < 0.0001). When the indexes related to the AUCC were less than the inflection point value, they were significantly negatively associated with DR.ConclusionsThe indexes related to the AUCC for six time periods during an oral glucose tolerance test and C‐peptide release test was closely associated with the incidence to DR in patients with type 2 diabetes. AUCC has the added advantage of being a cheap and convenient risk assessment over traditional ophthalmic screening.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3