Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein
Author:
Affiliation:
1. UCB Pharma; Braine l'Alleud Belgium
Funder
UCB Pharma
Publisher
Wiley
Subject
Neurology (clinical),Neurology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/epi.13638/fullpdf
Reference32 articles.
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2. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter;Feany;Cell,1992
3. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein;Gillard;Eur J Pharmacol,2006
4. Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties;Gillard;Eur J Pharmacol,2011
5. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam;Lynch;Proc Natl Acad Sci U S A,2004
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