Safety and tolerability of elbasvir/grazoprevir in chronic hepatitis C virus therapy: Integrated analysis from clinical trials

Author:

Nangia Gayatri1,Vierling John M.2,Kwo Paul3,Brown Deborah D.4,Klopfer Stephanie O.4,Robertson Michael N.4,Haber Barbara A.4,Reddy K. Rajender1ORCID

Affiliation:

1. Department of Medicine Division of Gastroenterology and Hepatology University of Pennsylvania Philadelphia PA USA

2. Departments of Medicine and Surgery Baylor College of Medicine Houston TX USA

3. Department of Medicine—Gastroenterology and Hepatology Stanford University School of Medicine Palo Alto CA USA

4. Merck & Co., Inc. Kenilworth NJ USA

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

Reference24 articles.

1. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

2. Review article: safety and tolerability of direct-acting anti-viral agents in the new era of hepatitis C therapy

3. EASL Recommendations on Treatment of Hepatitis C 2018

4. US Food and Drug Administration. Safety Announcement. FDA warns about rare occurrence of serious liver injury with use of hepatitis C medicines Mavyret Zepatier and Vosevi in some patients with advanced liver disease. August 28 2019. Accessed November 25 2019.https://www.fda.gov/drugs/drug‐safety‐and‐availability/fda‐warns‐about‐rare‐occurrence‐serious‐liver‐injury‐use‐hepatitis‐c‐medicines‐mavyret‐zepatier‐and.)

5. Efficacy and safety of 12 weeks of elbasvir ± grazoprevir ± ribavirin in participants with hepatitis C virus genotype 2, 4, 5 or 6 infection: The C‐SCAPE study

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