Evaluation of time in tight range and the glycaemia risk index in adults with type 1 diabetes using an advanced hybrid closed loop system: A 1‐year real‐world assessment

Author:

Rizzi Alessandro1ORCID,Tartaglione Linda1,Lucaccini Paoli Lorenzo1,Leo Maria Laura1,Popolla Valentina1,Viti Luca1,Barberio Annarita1,Di Leo Mauro1,Pontecorvi Alfredo2,Pitocco Dario1

Affiliation:

1. Diabetes Care Unit, Fondazione Policlinico Agostino Gemelli Universita' Cattolica del Sacro Cuore Rome Italy

2. Department of Endocrinology, Fondazione Policlinico Agostino Gemelli Universita' Cattolica del Sacro Cuore Rome Italy

Abstract

AbstractAimTo assess the long‐term glycaemic outcomes, with additional metrics, in adults with type 1 diabetes (T1D) using the Tandem t:slim X2 with Control‐IQ technology advanced hybrid closed‐loop (AHCL) system.MethodsThis was a single‐centre, retrospective study involving 56 T1D patients who transitioned to the Tandem t:slim X2 with Control‐IQ system. The primary and secondary endpoints consisted of variations in time in tight range (TiTR; 70‐140 mg/dL) and the glycaemia risk index (GRI), respectively. Additional standardized continuous glucose monitoring (CGM) metrics, mean sensor glucose, coefficient of variation, the glucose management indicator (GMI), HbA1c and insulin daily dose, were also evaluated. Variables were measured at baseline and at 15 days, 3 months, 6 months and 1 year after Tandem t:slim X2 Control‐IQ initiation. Glucose outcomes are expressed as mean (standard deviation).ResultsUse of Tandem t:slim X2 with Control‐IQ over 1 year was associated with an increase in mean TiTR, from 38.11% (17.05%) to 43.10% (13.20%) (P = .059), and with a decline in the GRI, from 41.03 (25.48) to 28.55 (16.27) (P = .008). CGM metrics, including time in range and time above range, showed consistent improvements. Mean sensor glucose, the GMI and HbA1c decreased significantly over time. After an initial increase, insulin daily dose remained stable throughout the 12 months.ConclusionsThe results highlight the sustained effectiveness of Tandem t:slim X2 with Control‐IQ in improving glycaemic outcomes over 1 year and support the use of this technology for the management of T1D.

Publisher

Wiley

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