Real-world variability in dabigatran levels in patients with atrial fibrillation

Author:

Chan N. C.1,Coppens M.2,Hirsh J.3,Ginsberg J. S.34,Weitz J. I.34,Vanassche T.1,Douketis J. D.34,Schulman S.34,Eikelboom J. W.134

Affiliation:

1. Population Health Research Institute; Hamilton ON Canada

2. Department of Vascular Medicine; Academic Medical Center; Amsterdam the Netherlands

3. Department of Medicine; McMaster University; Hamilton ON Canada

4. Thrombosis and Atherosclerosis Research Institute; Hamilton ON Canada

Funder

Hamilton Health Sciences New Investigator

Boehringer Ingelheim

Publisher

Wiley

Subject

Hematology

Reference16 articles.

1. Dabigatran versus warfarin in patients with atrial fibrillation;Connolly;N Engl J Med,2009

2. Health Canada Pradaxa product monograph DIN 02312441 http://webprod5.hc-sc.gc.ca/dpd-bdpp/index-eng.jsp

3. U.S. Food and Drug Administration Pradaxa prescribing information http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022512s017lbl.pdf

4. European Medicines Agency Pradaxa summary of product characteristics http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf

5. The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy);Reilly;J Am Coll Cardiol,2014

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