Identification of compounds inhibiting prion replication and toxicity by removing PrPCfrom the cell surface-Reference-Cited by-同舟云学术

Identification of compounds inhibiting prion replication and toxicity by removing PrPCfrom the cell surface

Published:2019-07-18 Issue:1 Volume:152 Page:136-150
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Biggi Silvia¹,Pancher Michael²,Stincardini Claudia¹,Luotti Silvia³,Massignan Tania²,Dalle Vedove Andrea⁴,Astolfi Andrea⁵,Gatto Pamela²,Lolli Graziano⁴,Barreca Maria Letizia⁵,Bonetto Valentina³,Adami Valentina²,Biasini Emiliano¹^ORCID

Affiliation:

1. Dulbecco Telethon Laboratory of Prions and Amyloids Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento Trento Italy

2. HTS Core Facility Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento Trento Italy

3. Department of Molecular Biochemistry and Pharmacology Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy

4. Laboratory of Protein Crystallography and Structure‐Based Drug Design Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento Trento Italy

5. Department of Pharmaceutical Sciences University of Perugia Perugia Italy

Funder

Fondazione Telethon

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.14805

Reference52 articles.

1. The sheddase ADAM10 is a potent modulator of prion disease

2. Chemistry: Chemical con artists foil drug discovery