The CRYOSTAT2 trial: The rationale and study protocol for a multi‐Centre, randomised, controlled trial evaluating the effects of early high‐dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation

Author:

Curry Nicola1ORCID,Davenport Ross2ORCID,Lucas Joanne3ORCID,Deary Alison3ORCID,Benger Jonathan4ORCID,Edwards Antoinette5ORCID,Evans Amy3ORCID,Foley Claire3ORCID,Green Laura67ORCID,Morris Stephen8,Thomas Helen9ORCID,Brohi Karim2ORCID,Stanworth Simon J.10ORCID

Affiliation:

1. Oxford UniversityHospitals NHS Foundation Trust Nuffield Orthopaedic Hospital Oxford UK

2. Centre for Trauma Sciences, Blizard Institute Queen Mary University of London London UK

3. NHS Blood and Transplant Clinical Trials Unit Cambridge UK

4. Faculty of Health and Applied Sciences University of the West of England Bristol UK

5. Trauma Audit and Research Network Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust Salford UK

6. Blizard Institute Queen Mary University of London London UK

7. NHS Blood and Transplant and Bart's Health NHS Trust London UK

8. Department of Public Health and Primary Care University of Cambridge Cambridge UK

9. NHS Blood and Transplant Clinical Trials Unit Bristol UK

10. NHS Blood and Transplant and Oxford University Hospitals NHS Foundation Trust John Radcliffe Hospital Oxford UK

Funder

National Institute for Health Research

Publisher

Wiley

Subject

Hematology

Reference38 articles.

1. World Health Organization (WHO).Injuries and violence. WHO;2021.https://www.who.int/news‐room/fact‐sheets/detail/injuries‐and‐violence

2. World Health Organization (WHO).Road traffic injuries;2021.https://www.who.int/news‐room/fact‐sheets/detail/road‐traffic‐injuries

3. NIHRPGfAR 10036: Traumatic Coagulopathy and Massive Transfusion: Improving outcomes and saving blood.https://fundingawards.nihr.ac.uk/award/RP‐PG‐0407‐10036

4. Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England

5. Acute Traumatic Coagulopathy

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