Impact of UGT1A1 genotype on the efficacy and safety of irinotecan‐based chemotherapy in metastatic colorectal cancer

Author:

Iwasa Satoru1ORCID,Muro Kei2,Morita Satoshi3,Park Young Suk4,Nakamura Masato5,Kotaka Masahito6,Nishina Tomohiro7,Matsuoka Hiroshi8,Ahn Joong Bae9,Lee Keun‐Wook10,Hong Yong Sang11,Han Sae Won12,Cho Sang‐Hee13ORCID,Zhang Dong‐Sheng14,Fang Wei‐Jia15ORCID,Bai Li16,Yuan Xiang‐Lin17,Yuan Ying18,Yamada Yasuhide1920,Sakamoto Junichi21,Kim Tae Won11

Affiliation:

1. Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Tokyo Japan

2. Department of Clinical Oncology Aichi Cancer Center Hospital Nagoya Japan

3. Department of Biomedical Statistics and Bioinformatics Graduate School of Medicine Kyoto University Kyoto Japan

4. Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea

5. Department of Chemotherapy Comprehensive Cancer Center Aizawa Hospital Matsumoto Japan

6. Department of Digestive Surgery Gastrointestinal Cancer Center Sano Hospital Kobe Japan

7. Department of Gastroenterology National Hospital Organization Shikoku Cancer Center Matsuyama Japan

8. Department of General Gastroenterological Surgery Fujita Health University Hospital Toyoake Japan

9. Department of Internal Medicine Yonsei University College of Medicine Seoul Korea

10. Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea

11. Department of Oncology Asan Medical Center University of Ulsan, College of Medicine Seoul Korea

12. Department of Internal Medicine Seoul National University Hospital Seoul Korea

13. Department of Hematology‐Oncology Chonnam National University Hospital, Medical School Gwangju Korea

14. Department of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou China

15. Department of Medical Oncology First Affiliated Hospital Zhejiang University Hangzhou China

16. Department of Medical Oncology Chinese PLA General Hospital Beijing China

17. Department of Gastrointestinal Oncology Tongji Hospital Huazhong University of Science and Technology Wuhan China

18. Department of Medical Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

19. Comprehensive Cancer Center National Center for Global Health and Medicine Shizuoka Japan

20. Department of Medical Oncology Hamamatsu University School of Medicine Shizuoka Japan

21. Tokai Central Hospital Kakamigahara Japan

Funder

Chugai Pharmaceutical

F. Hoffmann-La Roche

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

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