Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III

Author:

Ghosh Laskar M.123,Eriksson M.1,Rudling M.123,Angelin B.123

Affiliation:

1. Metabolism Unit; Department of Endocrinology, Metabolism and Diabetes; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

2. Molecular Nutrition Unit; Center for Innovative Medicine (CIMED); Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

3. KI/AZ Integrated CardioMetabolic Center (ICMC); Department of Medicine; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

Funder

Vetenskapsrådet

Kommunfullmäktige, Stockholms Stad

Hjärt-Lungfonden

Leducq Foundation

NovoNordisk Foundation

Knut och Alice Wallenbergs Stiftelse

Cardiovascular Program of Karolinska Institute/Stockholm County Council

Publisher

Wiley

Subject

Internal Medicine

Reference48 articles.

1. Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids;Bramlett;Mol Genet Metab,2000

2. Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription;Chiang;J Biol Chem,2000

3. Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism;Adler;Gastroenterology,1975

4. Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients;LaRusso;Gastroenterology,1975

5. The effect of chenodeoxycholic acid feeding on bile acid kinetics and fecal neutral steroid excretion in patients with hyperlipoproteinemia types II and IV;Kallner;J Lab Clin Med,1975

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