Assessment of the efficacy of a novel tailored vitamin K dosing regimen in lowering the International Normalised Ratio in over-anticoagulated patients: a randomised clinical trial

Author:

Kampouraki Emmanouela1,Avery Peter J.2,Wynne Hilary3,Biss Tina4,Hanley John4,Talks Kate4,Kamali Farhad1ORCID

Affiliation:

1. Institute of Cellular Medicine, Newcastle University; Newcastle upon Tyne UK

2. School of Mathematics & Statistics, Newcastle University; Newcastle upon Tyne UK

3. Older People's Medicine; Freeman Hospital; Newcastle upon Tyne UK

4. Department of Haematology; Royal Victoria Infirmary; Newcastle upon Tyne United Kingdom

Funder

National Institute for Health Research

Research for Patient Benefit (RfPB) Programme

Publisher

Wiley

Subject

Hematology

Reference34 articles.

1. A randomized trial comparing 1 mg of oral vitamin K with no treatment in the management of warfarin-associated coagulopathy in patients with mechanical heart valves;Ageno;Journal of the American College of Cardiology,2005

2. VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children;Biss;Blood,2012

3. Reversal of warfarin-induced over-anticoagulation with individualized dosing of oral vitamin K: a pilot study;Briz;Journal of Thrombosis and Haemostasis,2010

4. Chibisov , I. 2007 Strategies for Reversal of Anticoagulants, Part I: Warfarin, Unfractionated Heparin and Low Molecular Weight Heparins. Transfusion Medicine Update, Institute for Transfusion Medicine, issue 5 http://www.itxm.org/tmu/tmu2007/2007ISSUE5.pdf

5. Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial;Crowther;Lancet,2000

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