Harnessing antimicrobial peptides in endodontics

Author:

Kong Xinzi1,Vishwanath Vijetha2,Neelakantan Prasanna3ORCID,Ye Zhou1ORCID

Affiliation:

1. Applied Oral Sciences and Community Dental Care, Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China

2. Division of Restorative Dental Sciences, Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China

3. Department of Endodontics University of the Pacific Arthur A. Dugoni School of Dentistry San Francisco California USA

Abstract

AbstractEndodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target microbiota, eliminate biofilms, modulate inflammation and promote tissue repair. However, no current endodontic agents can achieve these goals. Antimicrobial peptides (AMPs), which are sequences of amino acids, have gained attention due to their unique advantages, including reduced susceptibility to drug resistance, broad‐spectrum antibacterial properties and the ability to modulate the immune response of the organism effectively. This review systematically discusses the structure, mechanisms of action, novel designs and limitations of AMPs. Additionally, it highlights the efforts made by researchers to overcome peptide shortcomings and emphasizes the potential applications of AMPs in endodontic treatments.

Publisher

Wiley

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