Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation
Author:
Affiliation:
1. Department of Surgery; Transplant; Indiana University School of Medicine; Indianapolis; IN; USA
Publisher
Wiley
Subject
Transplantation,Immunology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/xen.12019/fullpdf
Reference17 articles.
1. Production of alpha 1,3-galactosyltransferase-deficient pigs;Phelps;Science,2002
2. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations;Kolber-Simonds;Proc Natl Acad Sci U S A,2004
3. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys;Chen;Nat Med,2005
4. Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation;Song;Biochem J,2010
5. Loss of N-glycolylneuraminic acid in humans: mechanisms, consequences, and implications for hominid evolution;Varki;Yearb Phys Anthropol,2001
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