Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma-Reference-Cited by-同舟云学术

Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma

Published:2024-03 Issue:7 Volume:44 Page:1588-1599
ISSN:1478-3223
Container-title:Liver International
language:en
Short-container-title:Liver International

Author:

Giannini Edoardo G.¹²^ORCID,Pasta Andrea¹²^ORCID,Pieri Giulia¹²^ORCID,Plaz Torres Maria Corina¹²^ORCID,Marseglia Mariarosaria³⁴,Pelizzaro Filippo⁵,Sangiovanni Angelo⁶^ORCID,Cabibbo Giuseppe⁷^ORCID,Ghittoni Giorgia⁸,Di Marco Mariella⁹,Foschi Francesco Giuseppe¹⁰,Guarino Maria¹¹^ORCID,Biasini Elisabetta¹²,Saitta Carlo¹³,Campani Claudia¹⁴^ORCID,Svegliati‐Baroni Gianluca¹⁵,Gasbarrini Antonio¹⁶^ORCID,Brunetto Maurizia Rossana¹⁷^ORCID,Magalotti Donatella¹⁸,Azzaroli Francesco¹⁹,Mega Andrea²⁰,Sacco Rodolfo²¹,Nardone Gerardo²²^ORCID,Sacerdoti David²³,Masotto Alberto²⁴,Vidili Gianpaolo²⁵^ORCID,Bucci Laura⁴²⁶,Vitale Alessandro²⁷^ORCID,Trevisani Franco⁴²⁶^ORCID,

Affiliation:

1. Gastroenterology Unit, Department of Internal Medicine University of Genoa Genoa Italy

2. IRCCS Ospedale Policlinico San Martino Genoa Italy

3. Division of Internal Medicine, Hepatobiliary Diseases and Immunoallergology University of Bologna Bologna Italy

4. IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna Italy

5. Department of Surgery, Oncology and Gastroenterology, Gastroenterology Unit University of Padua Padua Italy

6. Division of Gastroenterology and Hepatology Fondazione IRCCS Ca’ Granda Ospedale maggiore Policlinico and C.R.C. “A.M. & A. Migliavacca Center for Liver Disease” Milan Italy

7. Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, PROMISE, Gastroenterology & Hepatology Unit University of Palermo Palermo Italy

8. Gastroenterology Unit Belcolle Hospital Viterbo Italy

9. Medicine Unit Bolognini Hospital Seriate Italy

10. Department of Internal Medicine Ospedale per gli Infermi di Faenza Faenza Italy

11. Department of Clinical Medicine and Surgery, Diseases of the Liver and Biliary System Unit University of Naples "Federico II" Naples Italy

12. Infectious Diseases and Hepatology Unit Azienda Ospedaliero‐Universitaria di Parma Parma Italy

13. Department of Clinical and Experimental Medicine, Clinical and Molecular Hepatology Unit University of Messina Messina Italy

14. Department of Experimental and Clinical Medicine, Internal Medicine and Hepatology Unit University of Florence Florence Italy

15. Liver Injury and Transplant Unit Polytechnic University of Marche Ancona Italy

16. Liver Unit, CEMAD – Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Gemelli IRCCS Rome Italy

17. Department of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory University Hospital of Pisa Pisa Italy

18. Division of Internal Medicine, Neurovascular and Hepatometabolic Diseases IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna Italy

19. Gastroenterology Unit IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna Italy

20. Gastroenterology Unit Bolzano Regional Hospital Bolzano Italy

21. Gastroenterology and Digestive Endoscopy Unit Foggia University Hospital Foggia Italy

22. Department of Clinical Medicine and Surgery, Hepato‐Gastroenterology Unit University of Naples “Federico II” Naples Italy

23. Liver Unit, Department of Medicine University of Verona, Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy

24. Gastroenterology Unit Ospedale Sacro Cuore Don Calabria Negrar Italy

25. Department of Medical, Surgical and Experimental Sciences, Clinica Medica Unit University of Sassari, Azienda Ospedaliero‐Universitaria di Sassari Sassari Italy

26. Unit of Semeiotics, Liver and Alcohol‐related Diseases University of Bologna Bologna Italy

27. Department of Surgery, Oncology and Gastroenterology University of Padua Padua Italy

Abstract

AbstractBackground & AimsChronic hepatitis D virus (HDV) often leads to end‐stage liver disease and hepatocellular carcinoma (HCC). Comprehensive data pertaining to large populations with HDV and HCC are missing, therefore we sought to assess the characteristics, management, and outcome of these patients, comparing them to patients with hepatitis B virus (HBV) infection.MethodsWe analysed the Italian Liver Cancer database focusing on patients with positivity for HBV surface antigen and anti‐HDV antibodies (HBV/HDV, n = 107) and patients with HBV infection alone (n = 588). Clinical and oncological characteristics, treatment, and survival were compared in the two groups.ResultsPatients with HBV/HDV had worse liver function [Model for End‐stage Liver Disease score: 11 vs. 9, p < .0001; Child‐Turcotte‐Pugh score: 7 vs. 5, p < .0001] than patients with HBV. HCC was more frequently diagnosed during surveillance (72.9% vs. 52.4%, p = .0002), and the oncological stage was more frequently Milan‐in (67.3% vs. 52.7%, p = .005) in patients with HBV/HDV. Liver transplantation was more frequently performed in HBV/HDV than in HBV patients (36.4% vs. 9.5%), while the opposite was observed for resection (8.4% vs. 20.1%, p < .0001), and in a competing risk analysis, HBV/HDV patients had a higher probability of receiving transplantation, independently of liver function and oncological stage. A trend towards longer survival was observed in patients with HBV/HDV (50.4 vs. 44.4 months, p = .106).ConclusionsIn patients with HBV/HDV, HCC is diagnosed more frequently during surveillance, resulting in a less advanced cancer stage in patients with more deranged liver function than HBV alone. Patients with HBV/HDV have a heightened benefit from liver transplantation, positively influencing survival.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/liv.15855

Reference44 articles.

1. Hepatitis D Virus Infection

2. Hepatitis delta virus

3. Acute Delta Hepatitis in Italy spanning three decades (1991–2019): Evidence for the effectiveness of the hepatitis B vaccination campaign

4. The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

5. New epidemiology of hepatitis delta

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