Unjustified allegation on cancer risks in children of mothers with epilepsy taking high‐dose folic acid during pregnancy—No proof of a causal relationship

Author:

von Wrede Randi1ORCID,Witt Juri‐Alexander1ORCID,Auvin Stéphane234ORCID,Devlin Anita56ORCID,Lagae Lieven7ORCID,Marson Anthony89,Meador Kimford J.10ORCID,O'Brien Terence J.11,Park Jun12ORCID,Surges Rainer1ORCID,Trinka Eugen13141516ORCID,Wiebe Samuel17ORCID,Helmstaedter Christoph1ORCID

Affiliation:

1. Department of Epileptology University Hospital Bonn, Member of the European Reference Network EpiCARE Bonn Germany

2. Department of Pediatric Neurology AP‐HP, Robert‐Debré University Hospital, CRMR Épilepsies Rares, EpiCARE Member Paris France

3. Université Paris Cité, INSERM NeuroDiderot Paris France

4. Institut Universitaire de France (IUF) Paris France

5. Great North Children's Hospital Newcastle upon Tyne UK

6. Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK

7. Department Development and Regeneration KU Leuven, Member of the European Reference Network EpiCARE Leuven Belgium

8. Department of Pharmacology and Therapeutics University of Liverpool Liverpool UK

9. The Walton Centre, NHS Foundation Trust Liverpool UK

10. Department of Neurology & Neurological Sciences Stanford University Palo Alto California USA

11. The Department of Neuroscience, Central Clinical School Monash University Melbourne Victoria Australia

12. UH Rainbow Babies & Children's Hospital/UH Cleveland Medical Center Case Western Reserve University School of Medicine Cleveland USA

13. Department of Neurology Paracelsus Medical University Salzburg Austria

14. Christian Doppler Medical Centre Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE Salzburg Austria

15. Neuroscience Institute, Christian Doppler Medical Centre, Centre for Cognitive Neuroscience Salzburg Austria

16. Institute of Public Health, Medical Decision Making and Health Technology Assessment University for Health Sciences, Medical Informatics and Technology, UMIT Hall in Tyrol Austria

17. Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine University of Calgary Calgary Canada

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Reference19 articles.

1. Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy

2. ACOG Practice Bulletin: No. 44. July 2003. Neural Tube Defects

3. Healthcare Improvement Scotland.Scottish intercollegiate guidelines network. Diagnosis and Management of Epilepsy in Adults: A National Clinical Guideline. Accessed January 8 2022.https://www.sign.ac.uk/media/1079/sign143_2018.pdf2018.

4. National Institute for Health and Care Excellence.National Institute for clinical excellence. The diagnosis and management of the epilepsies in adults and children in primary and secondary care. Accessed January 8 2022.https://www.nice.org.uk/guidance/cg1372004.

5. Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding

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