Continuous dosing versus interrupted therapy with ixekizumab: an integrated analysis of two phase 3 trials in psoriasis

Author:

Blauvelt A.1,Papp K.A.2,Sofen H.3,Augustin M.4,Yosipovitch G.5,Katoh N.6,Mrowietz U.7,Ohtsuki M.8,Poulin Y.910,Shrom D.11,Burge R.11,See K.11,Mallbris L.11,Gordon K.B.12

Affiliation:

1. Oregon Medical Research Center; Portland OR USA

2. Probity Medical Research and K. Papp Clinical Research; Waterloo ON Canada

3. Department of Medicine (Dermatology); David Geffen School of Medicine; Los Angeles CA USA

4. Institute for Health Services Research in Dermatology and Nursing; University Medical Center Hamburg; Hamburg Germany

5. Department of Dermatology; Miller School of Medicine; University of Miami; Miami FL USA

6. Department of Dermatology; Kyoto Prefectural University of Medicine Graduate School of Medical Science; Kyoto Japan

7. Psoriasis-Center; Department of Dermatology; University Medical Center Schleswig-Holstein; Campus Kiel Germany

8. Department of Dermatology; Jichi Medical University; Shimotsuke Tochigi Japan

9. Department of Medicine; Université Laval; Hôpital Hôtel-Dieu de Québec; Quebec QC Canada

10. Centre de Recherche Dermatologique du Québec Métropolitain; Quebec QC Canada

11. Eli Lilly and Company; Indianapolis IN USA

12. Department of Dermatology; Feinberg School of Medicine; Northwestern University; Chicago IL USA

Funder

Eli Lilly and Company

Publisher

Wiley

Subject

Infectious Diseases,Dermatology

Reference19 articles.

1. Continuous versus intermittent therapy for moderate-to-severe psoriasis;Ramirez-Fort;Clin Exp Rheumatol,2013

2. Off-label biologic regimens in psoriasis: a systematic review of efficacy and safety of dose escalation, reduction, and interrupted biologic therapy;Brezinski;PLoS ONE,2012

3. A consensus report on appropriate treatment optimization and transitioning in the management of moderate-to-severe plaque psoriasis;Mrowietz;J Eur Acad Dermatol Venereol,2014

4. Adalimumab for moderate to severe chronic plaque psoriasis: efficacy and safety of retreatment and disease recurrence following withdrawal from therapy;Papp;Br J Dermatol,2011

5. Duration of remission of biologic agents for chronic plaque psoriasis;Langley;J Drugs Dermatol,2007

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