Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homoeostasis
Author:
Affiliation:
1. Department of Pharmacology School of Basic Medical Sciences Xi'an Jiaotong University, Health Science Center Xi'an China
2. Department of Pharmacology College of Pharmacy Xinxiang Medical University Xinxiang Henan 453003 China
Funder
National Natural Science Foundation of China
Publisher
Wiley
Subject
Pharmacology,Toxicology,General Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.13318
Reference44 articles.
1. Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer
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3. Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis
4. Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics
5. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
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