Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir

Author:

Prashar Vishal1,Bihani Subhash C.1,Ferrer Jean-Luc2,Hosur Madhusoodan V.

Affiliation:

1. Solid State Physics Division; Bhabha Atomic Research Centre; Trombay, Mumbai 400085 India

2. Institut de Biologie Structurale Jean-Pierre Ebel; Groupe Synchrotron; Commissariat a l'Energie Atomique et aux Energies Alternatives; Centre National de la Recherche Scientifique; Universite de Grenoble Alpes; Grenoble 38027 France

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference43 articles.

1. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS);Barré-Sinoussi;Science,1983

2. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS;Gallo;Science,1984

3. International AIDS Vaccine Initiative (IAVI) 2008 AIDS vaccine blueprint 2008: A challenge to the field, a roadmap for progress http://iavi.org/publications/file/34-aids-vaccine-blueprint-2008

4. HIV drug development: the next 25 years;Flexner;Nat Rev Drug Discov,2007

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