Design, Synthesis and Pharmacological Evaluation of Novel NO-Releasing Benzimidazole Hybrids as Potential Antihypertensive Candidate

Author:

Zhang Yanchun1,Xu Jinyi2,Li Yunman3,Yao Hequan2,Wu Xiaoming2

Affiliation:

1. Department of Medicinal Chemistry; Anhui University of Chinese Medicine; 103 Meishan Road Hefei 230031 China

2. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry; China Pharmaceutical University; 24 Tong Jia Xiang Nanjing 210009 China

3. Department of Physiology; China Pharmaceutical University; 24 TongJia Xiang Nanjing 210009 China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference16 articles.

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2. Nitric oxide and its role in the cardiovascular system;Loscalzo;Prog Cardiovasc Dis,1995

3. Nitric oxide insufficiency and atherothrombosis;Voetsch;Histochem Cell Biol,2004

4. Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists;Tellew;Bioorg Med Chem Lett,2003

5. The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischaemia-reperfusion in the anaesthetized rat;Rossoni;J Pharmacol Exp Ther,2001

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