Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure-Reference-Cited by-同舟云学术

Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure

Published:2014-12-08 Issue:2 Volume:86 Page:200-209
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Alam Shahabuddin¹,Javor Sacha²,Degardin Melissa²,Ajami Dariush²,Rebek Mitra²,Kissner Teri L.¹,Waag David M.¹,Rebek Julius²,Saikh Kamal U.¹

Affiliation:

1. Department of Immunology; Army Medical Research Institute of Infectious Diseases; 1425 Porter Street Frederick MD 21702 USA

2. Department of Chemistry; The Skaggs Institute for Chemical Biology; The Scripps Research Institute; 10550 North Torrey Pines Road La Jolla CA 92037 USA

Funder

The Defense Threat Reduction Agency

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12477/fullpdf

Reference22 articles.

1. Toll-like receptor signaling;Akira;Nat Rev Immunol,2004

2. The role of MyD88-like adapters in Toll-like receptor signal transduction;O'Neill;Biochem Soc Trans,2003

3. MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA;Sun;Nat Immunol,2006